On September 24th, 2021, con.Scienze organized a one-day conference to reflect on the experience of on-line teaching. The conference featured trans-disciplinary contributions and disciplinary sessions, which allowed the sharing of good practices
and the discussion of the many critical aspects of online training. This is a short report of the conference and, more in details, of the parallel session devoted to chemistry. We also offer some provocative reflections on the experience of on-line teaching.